Over the past few decades, scaling in fabrication technology has enabled drastic improvements in performance, cost/area, and power dissipation of integrated circuits. Synchronous design style has played an essential role in this rapid growth of commercial microchips and EDA tools. However, challenges in state-of-the-art fabrication technologies, such as process variation, design reuse (portability), tight timing & power budgets, etc. have motivated researchers to explore asynchronous design styles for conventional computing applications as well as emerging applications in physical sciences. My research vision is to identify critical features/properties of the current Asynchronous VLSI design styles, which made them so successful, and transform them for future general-purpose computing applications and specialized applications in physical sciences.